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Drug Sensitivity Plan(DS2)

Drug Sensitivity Plan(DS2)

HK$1,090.00
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Description

Comprehensive Genetic Wellness Checkup
Studies have shown that cats and dogs are at least 100 times more likely than human to develop genetic disorders. An animal may appear healthy now, however, it can develop genetic disease later in life and pass the defective gene to future generations. Amvet Biosciences can unlock the genetic code of DNA empowering you to plan and act proactively at an early stage.

The Drug Sensitivity Plan (DS2) includes the following canine DNA tests

• Multi Drug and Ivermectin Sensitivity (MDR1) 

MDR1 results from a mutation in the multi-drug resistance gene. This gene encodes a glycoprotein that is responsible for pumping many drugs and other toxins out of the brain. Dogs with the mutant gene cannot pump certain drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. The result may be an illness requiring an extended hospital stay or even death. This test is most commonly used for Ivermectin sensitivity but many other drugs are responsible for MDR1 symptoms. MDR1 is more common in Collies and related breeds.


• Malignant Hyperthermia (MH)

Malignant Hyperthermia or malignant hyperpyrexia is an autosomal dominant genetic mutation. It is a life-threatening condition that is usually triggered by exposure to certain drugs used for general anaesthesia, specifically the volatile anaesthetic agents and the neuromuscular blocking agent. Pets predisposed to malignant hyperthermia are also sensitive to certain ingredients present in drugs and food such as caffeine. In susceptible animals, these drugs can induce a drastic and uncontrolled increase in muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature, eventually leading to circulatory collapse and death if not treated quickly. Breed with the highest risk of MH includes Australian Shepherd, Collie and Long-haired Whippet. However, the carrier frequency of the disease gene in German Shepherd is about 10% and in mixed-breed dog is about 5%.



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