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Comprehensive Plan (GH4)

Comprehensive Plan (GH4)

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Comprehensive Genetic Wellness Checkup
Studies have shown that cats and dogs are at least 100 times more likely than human to develop genetic disorders. An animal may appear healthy now, however, it can develop genetic disease later in life and pass the defective gene to future generations. Amvet Biosciences can unlock the genetic code of DNA empowering you to plan and act proactively at an early stage.

The Comprehensive Plan (GH4) includes the following feline DNA tests

• Familial Hypertrophic Cardiomyopathy (HCM) 

FHC is an inherited disorder identify in British Shorthairs, Maine Coons, Ragdolls and Scottish Fold. It is a condition characterised by thickening of the heart muscle resulting in a reduced volume within the ventricles (major chambers of the heart), thus reducing the volume of blood that the heart can pump with each contraction. Affected animal is at risk of developing congestive heart failure and occasionally sudden death. The mutation does not behave as a simple dominant trait, but rather as a dominant trait within complete penetrance. Cats with one copy of the mutant gene are 1.8 times more likely to develop FHC than normal cats. Cats with two copies of the mutant generally 18 times more likely to develop FHC than normal cats. About 9% of British Shorthair and 30% of Maine Coon are affected by FHC.

• Hyperoxaluria (HOU)

HOU is characterized by the accumulation of oxalate andsubsequent precipitation of calcium oxalate crystals, primarily in the kidneys(kidney stone), leading to progressive kidney failure. In addition to theclinical signs due to kidney failure the affected animals became very weak.Calcium oxalate crystals can also accumulate in skeletal muscle and spinal cordaffecting mobility. It has been reported in a number of breeds, includingDomestic Short Hair and Ragdoll.

• Polycystic Kidney Disease (PKD) 

PKD is the most common inherited cause of kidney failure in cats. PKD mutations have been found in many other cat breeds including Exotics, Himalayans, British Shorthairs, American Shorthairs, Ragdolls and Scottish Fold. The disease shows up later in life (late onset). The cysts usually grow quite slowly in the kidney, so most affected cats will not show any signs of kidney disease until they are older. Problems occur when these cysts start to grow and progressively enlarge the kidney, reducing the kidney's ability to function properly. This usually occurs between 3 and 10 years of age (on average at 7 years of age). However, in some cats kidney failure will occur at a much younger age and at the moment there is no way of predicting how rapidly the disease will progress in any particular cat. Ultimately PKD leads to kidney failure. It is estimated over 37% of Persians have PKD.

• Vitamin D-dependentrickets (VDDR)

VDDR is a genetic disorder of the bones normally caused byan abnormal vitamin D and calcium levels in the body. It is characterized by anincreased prevalence of fractures and deformity. Some cats may have a hunchedappearance, swollen limbs, a reluctance to jump and a decreased appetite.Therapy with calcitriol, the active form of vitamin D, and calcium may help torelieve the symptom.

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